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Figure 6 | Journal of Neuroinflammation

Figure 6

From: The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage

Figure 6

The effects of microglial ablation on vasospasm. A. Top panels: microglial staining with Iba1 at the level of the hippocampus of wild type subarachnoid hemorrhage SAH on post-operative days (PODs) 7 and 15 after intracerebroventricular (ICV) injection of control PBS liposomes. B. Bottom panels: microglial depletion in wild type SAH on PODs 7 and 15 after ICV injection with clodronate liposomes. Scale Bars: 10 μm in all panels. C. Quantification of microglial cells in the hippocampal area of wild type SAH mice with ICV injections of PBS liposomes and clodronate liposomes. N = 3 for each group and error bars are standard deviations. Comparison by Student’s t-test on POD 7 and POD 15 between clodronate and PBS liposomes injections shows significant depletion on both days (P <0.03). D. Measurement of vasospasm shows significant ablation of vasospasm at both time points after microglial depletion by Student’s t-test: POD 7 (P <0.001) and POD 15 (P <0.001). N = 3 mice for each group.

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