Skip to main content
Figure 9 | Journal of Neuroinflammation

Figure 9

From: M-CSF increases proliferation and phagocytosis while modulating receptor and transcription factor expression in adult human microglia

Figure 9

Macrophage colony-stimulating factor (M-CSF) increases adult human microglial expression of CSF-1R and IGF-1R. M-CSF treatment does not significantly alter the total number of Hoechst-labeled nuclei in human adult mixed glial cultures (A and E), but it does increase the number of microglia (B and F), as shown by labeling for the microglial transcription factor PU.1. Together with an increase in microglia number, M-CSF produces an increase in microglial expression of its receptor CSF-1R (C and G) and the receptor for IGF-1 (D and H). A significant increase in intensity of receptor labeling is found for both CSF-1R (I; P < 0.0001, n = 8) and IGF-1R (J; P < 0.01, n = 8) following M-CSF treatment. Scale bar = 50 μm.

Back to article page