From: Diverse activation of microglia by chemokine (C-C motif) ligand 2 overexpression in brain
Accession_ID | Gene symbol | Description | Fold change CCL2/Control | P-value | Function |
---|---|---|---|---|---|
M1 genes | |||||
NM_010766 | Marco | Macrophage receptor with collagenous structure | 0.6 ↓ | P < 0.004 | Scavenger receptor expressed in a subset of macrophages [39] |
NM_001002898 | Sirpβ | Signal-regulatory protein β | 17.13↑ | P < 0.002 | Cytoskeleton rearrangement, counterregulates proinflammatory mediators, phagocytosis [40] |
NM_013650 | S100A8 | S100 calcium-binding protein A8 (calgranulin A) | 3.1↑ | P < 0.03 | Calcium-binding protein involved in innate immune response [41] |
NM_009114 | S100A9 | S100 calcium-binding protein A9 (calgranulin B) | ND | ||
NM_011593 | Timp1 | Tissue inhibitor of metalloproteinase 1 | ND | Inhibitory role against most matrix metalloproteinases, promotes cell proliferation [45, 46] | |
NM_010927 | iNOS | Nitric oxide synthase, inducible | ND | Immune defense against pathogens, induces inflammation and oxidative stress [47] | |
NM_001111274 | IGF-1 | Insulin-like growth factor 1 | ND | Mammalian growth and development [48] | |
M2 genes | |||||
NM_007482 | Arg1 | Arginase 1, liver | 2.4↑ | P < 0.006 | Arginine and proline metabolism [49] |
NM_007695 | Chi3l3 | Chitanase 3-like 3 | 2.7↑ | P < 0.003 | Expressed in myeloid precursor cells, involved in inflammation (alternative activated macrophages) [27] |
NM_020509 | Retnla | Resistin-like α | ND | Alternatively activated macrophages and tissue repair [50] | |
Chemotactic (M2) genes | |||||
NM_019577 | CCL24 | C-C motif chemokine 24 | 1.7↑ | P < 0.04 | Chemotaxis [51] |
NM_001013412 | CCL26 | C-C motif chemokine 26 | ND | Induces migration of eosinophils macrophages and basophils [52] | |
NM_007894 | EAR1 | Eosinophil-associated, ribonuclease A family, member 1 | ND | RNase activity, chemotactic for eosinophils, alveolar macrophages [53] | |
NM_007895 | EAR2 | Eosinophil-associated, ribonuclease A family, member 2 | 3.8↑ | P < 0.02 | RNase activity, chemotactic for eosinophils, alveolar macrophages [53] |
NM_053113 | EAR11 | Eosinophil-associated, ribonuclease A family, member 11 | ND | RNase activity, chemotactic for eosinophils, alveolar macrophages [53] |