Figure 3

Brain mRNA expression of proinflammatory cytokines, but not sickness behavior, is increased by intracerebroventricular lipopolysaccharide. Both wild-type (WT) and indoleamine-2,3-dioxygenase (IDO1) knockout (KO) mice exhibit increased steady-state mRNA expression of (a) IL-1β and (b) TNFα, but not of (c) IL-6 in the whole brain 24 hours post intracerebroventricular (ICV) lipopolysaccharide (LPS, 10 ng). Exploratory locomotor activity measured by (d) distance traveled or (e) duration of time during the test spent moving were not different 24 hours after ICV LPS. Data are average ± standard error of the mean. n = 4 to 5 mice per group.