Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors

Table 1 Kynurenine and tryptophan 24 hours after treatment

	Control	Lipopolysaccharide
Brain
Kynurenine (nmol/mg wet weight)	0.09 ± 0.03^A	0.26 ± 0.04 ^B
Tryptophan (nmol/mg wet weight)	1.16 ± 0.27^A	1.45 ± 0.09^A
Kynurenine:tryptophan	0.07 ± 0.02^A	0.19 ± 0.03 ^B
Plasma
Kynurenine (μmol/l)	0.89 ± 0.1^A	0.99 ± 0.1^A
Tryptophan (μmol/l)	44.27 ± 1.84^A	47.63 ± 3.46^A
Kynurenine:tryptophan	0.020 ± 0.002^A	0.021 ± 0.003^A

Brain and plasma were collected for analysis of kynurenine and tryptophan concentrations using HPLC. Data are average concentrations ± standard error of the mean. Averages within rows with different uppercase superscript letters are significantly different; P <0.05. n = 6 to 7 mice per group.

ISSN: 1742-2094