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Table 1 Kynurenine and tryptophan 24 hours after treatment

From: Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors

  Control Lipopolysaccharide
Brain   
 Kynurenine (nmol/mg wet weight) 0.09 ± 0.03A 0.26 ± 0.04 B
 Tryptophan (nmol/mg wet weight) 1.16 ± 0.27A 1.45 ± 0.09A
 Kynurenine:tryptophan 0.07 ± 0.02A 0.19 ± 0.03 B
Plasma   
 Kynurenine (μmol/l) 0.89 ± 0.1A 0.99 ± 0.1A
 Tryptophan (μmol/l) 44.27 ± 1.84A 47.63 ± 3.46A
 Kynurenine:tryptophan 0.020 ± 0.002A 0.021 ± 0.003A
  1. Brain and plasma were collected for analysis of kynurenine and tryptophan concentrations using HPLC. Data are average concentrations ± standard error of the mean. Averages within rows with different uppercase superscript letters are significantly different; P <0.05. n = 6 to 7 mice per group.