Figure 4

Effect of dexamethasone on the pro-inflammatory response elicited by B. burgdorferi in primary rhesus DRG cultures. The levels of CCL2 (A), IL-6 (B) and IL-8 (C), respectively, in rhesus DRG cultures stimulated with live B. burgdorferi spirochetes for 24 hours at a MOI of 10:1 and in medium controls (* P <0.05, ** P <0.01) in the presence and absence of dexamethasone and carrier HPC are shown. Data represent mean values and standard deviations between values of duplicate wells that were seeded from DRG cells that were isolated from two adult rhesus macaques. DRG, dorsal root ganglia; HPC, (2-hydroxypropyl)-β-cyclodextrin; MOI, multiplicity of infection.