Effect of co-ultraPEALut on PPARα, PPARβ/δ and PPARγ expression. PPARα, PPARβ/δ and PPARγ expression were evaluated by western blot analysis. The mechanical damage induced a decrease in (a,a1) PPARα , (b,b1) PPARβ/δ and (c,c1) PPARγ expression compared to the control group. Co-ultraPEALut pretreatment at the three concentrations significantly restored the levels of both PPARα and PPARβ/δ; PPARγ expression was restored by co-ultraPEALut 0.0009 g/l (containing PEA and Lut at 2.7 and 0.27 μM, respectively) and 0.009 g/l (containing PEA and Lut at 27 and 2.7 μM, respectively). **P <0.01 and ***P <0.001 versus Ctr; #
P <0.05 and ##
P <0.01 versus Damage. Ctr, control; Lut, luteolin; PEA, palmitoylethanolamide; PPAR, peroxisome proliferator-activated receptor.