Figure 3

COX2 and NOS2 expression in neurons treated with sunitinib and NF-κB inhibitors. Neuronal cultures were treated with sunitinib (500 nM, 24 h) with or without the NF-κB inhibitors dicoumarol (25 μM), SN50 (5 μM) or Bay11-7085 (5 μM). Levels of COX2 and NOS2 were determined by western blot analysis. Data are mean ± SEM from three experiments. *P < 0.05, ***P < 0.001 vs. control; ^# P < 0.05, ^##0.01 vs. sunitinib alone. Bay, Bay11-7085; DIC, dicoumarol; SEM, standard error of the mean; SN, SN50; Su, sunitinib.