Sunitinib enhances neuronal survival in vitro via NF-κB-mediated signaling and expression of cyclooxygenase-2 and inducible nitric oxide synthase

Table 1 Effect of NF-κB inhibitors on neuronal survival and release of lactate dehydrogenase

	Neuronal survival^a	Lactate dehydrogenase released^b
Control	100.2 ± 3.8	100.1 ± 3.9
Sunitinib	127.7 ± 7.8 **	85.9 ± 2.9 **
Sunitinib + SN50	98.8 ± 6.1 ^##	123.9 ± 2.7 ^###
Sunitinib + Bay11-7085	83.0 ± 7.9 ^###	123.6 ± 2.7 ^###
Sunitinib + dicoumarol	110.4 ± 12.6	100.4 ± 5.7 ^#

^aCell survival was measured by MTT assay. Data are mean ± SEM from three experiments.
^bCell death was determined by level of released lactate dehydrogenase. Data are mean ± SEM from three experiments.
**P < 0.01 vs control.
^# P < 0.05, ^## P < 0.01, ^### P < 0.001 vs sunitinib alone.
SEM, standard error of the mean.

ISSN: 1742-2094