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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis

Figure 1

CD8 + T cell multispecificity to apoptotic epitopes in healthy donors and multiple sclerosis patients. (A) Mean number of IFN-γ spots formed by fresh CD8+ T effector memory (TEM) cells (by enzyme-linked immunospot assay) in response to 12 pools (see Additional file 1: Table S1A-C) of apoptotic self-epitopes in 26 HLA-A2+ patients with multiple sclerosis (MS) (dark bars) or 27 HLA-A2+ healthy donors (HDs) (clear bars). n.s., not significant. (B) Sum of IFN-γ spots formed by fresh CD8+ TEM cells in response to all pools (see Additional file 1: Table S1A-C) of apoptotic self-epitopes in the single patients or HDs. Each circle represents a single patient or a single HD. Statistical analysis was performed with the Mann-Whitney test. RLA, 60S acidic ribosomal protein P2; PSA, proteosome component C3; VIME, vimentin; GDIS, GDP dissociation inhibitor 2; Myh9, non-muscle myosin heavy chain 9; LAM1, lamin B1; ROK, heterogeneous nuclear ribonucleoprotein; ACTB, actin cytoplasmic 1.

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