Figure 2
Alteration in hippocampal mean diffusivity (MD) in middle cerebral artery occlusion (MCAO) rats visualized by MD map. Diffusion-weighted anatomic images of the brains from the intact, sham, and 1-week, 3-weeks, and 2-months after MCAO groups (A). MD color maps were created by MATLAB in the same slice for each group (B). Enlarged images of the boxed hippocampal areas of the sham and 1 week after MCAO brains shown in B (C). The infarcted area shows an unusually high MD value in the ipsilateral side (left) of the brain. Meanwhile, the white arrowhead indicates MD decreasing on the ipsilateral side of the hippocampus. MD values ranged from 0 to 5.0 × 10-4 (mm2/sec), as shown in the color bar below. All slices were obtained at bregma -3.30 to -3.80 mm.