Figure 5

Cognitive function was retained in P2Y ₁ KO mice after middle cerebral artery occlusion (MCAO). Contextual fear conditioning (A) and neurological (B) tests similar to the experiments with rats were performed. Both of the tests were conducted 1 week after MCAO. P2Y₁KO mice retained their hippocampus-dependent cognitive function, while they showed sensory motor deficits similar to WT mice. WT-sham, n = 18; WT-MCAO, n = 19; P2Y₁KO-sham, n = 14; P2Y₁KO-MCAO, n = 14. Values are means ± SEM. **P <0.01, ***P <0.001 in Tukey’s multiple comparison test.