Figure 7

Cognitive function in the acute phase and effect of blocking P2Y ₁ . A contextual fear conditioning test was conducted 4 days after middle cerebral artery occlusion (MCAO). The results were similar to those of the 1 week after MCAO group. The P2Y₁ receptor antagonist MRS2500 led to remarkably maintained cognitive function. MRS2500 was administered by pump, starting immediately after the 45-min MCAO. WT-sham, n = 7; WT-MCAO, n = 10; WT-MCAO-MRS2500, n = 5; P2Y₁KO-sham, n = 9; P2Y₁KO-MCAO, n = 8. Values are means ± SEM. **P <0.01, in Tukey’s multiple comparison test.