Figure 8
No decrease in hippocampal mean diffusivity (MD) value after middle cerebral artery occlusion (MCAO) in P2Y 1 KO-MCAO mice. Ex-vivo T2-weighted (A) and diffusion-weighted (B) images of the ipsilateral hemisphere. Regions of interest ( ROIs) for the hippocampal area were defined semi-automatically using ROI Editor (B). The MD value of the ipsilateral side of the brain from four groups was calculated (C). WT-sham, n = 4; WT-MCAO, n = 4; P2Y1KO-sham, n = 4; P2Y1KO-MCAO, n = 4. Values are means ± SEM. *P <0.05, **P <0.01, in Tukey’s multiple comparison test. Representative hippocampal MD maps from WT-MCAO (D) and P2Y1KO-MCAO (E) mice. MD maps were depicted by MATLAB. White arrowheads indicate the different MD values between the two groups at the ipsilateral side of the hippocampus. MD values ranged from 0 to 5.0 × 10-4 (mm2/sec), shown in the bar at right. All slices were obtained at bregma -1.80 to -2.30 mm.