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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression

Figure 3

Glial activation. Microglial activation and astrocytic activation, as shown by GFAP and GSB4 lectin immunohistochemistry, were not inhibited by chronic minocycline treatment. Sections from the visual cortex of chronically minocycline-treated CLN6 affected sheep stained for microglia with GSB4 lectin (A) similarly to sections from affected untreated sheep (B), whereas no staining was observed in the visual cortex of normal brain (F). Sections from the visual cortex of chronically minocycline-treated CLN6 affected sheep stained similarly for astrocytic activation with GFAP (C) to sections from affected untreated sheep (D), whereas no staining was observed in the visual cortex of normal brain (G). Nissl staining revealed the cortical layers in the visual cortex of a normal brain (E), indicated by roman numerals and also shown in (A). The pial surface (ps) is to the left in all images. Scale bars on (A) through to (G) represent 200 μm, and scale bars on the insets represent 50 μm.

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Journal of Neuroinflammation

ISSN: 1742-2094