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Table 1 Neurodegeneration and gross neuroinflammation after a year of treatment

From: Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression

 

        Mean thickness of layers (μm ± SEM)*

 

Layers

Treated affected

Untreated affected

Normal controls

I–V

1,063 ± 46

995 ± 43

1,285 ± 30

II–V

680 ± 34

728 ± 52

1,043 ± 28

GSB4 positive band

378 ± 29

351 ± 24

–

  1. *For three animals in each group and a minimum of 25 measurements per brain made in the visual cortex using the layer boundaries as defined in Figures 3A and E. GSB4, biotinylated α-D-galactose-specific isolectin I-B4 from Griffonia simplicifolia.
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Journal of Neuroinflammation

ISSN: 1742-2094