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Figure 1 | Journal of Neuroinflammation

Figure 1

From: T-cell reconstitution during murine acquired immunodeficiency syndrome (MAIDS) produces neuroinflammation and mortality in animals harboring opportunistic viral brain infection

Figure 1

Development of lymphopenia during murine acquired immunodeficiency syndrome. C57BL/6 mice were infected with the LP-BM5 retrovirus mixture and disease progression was assessed by determining the percentage of lymphocytes in peripheral blood at the indicated time points. Peripheral blood mononuclear cells (PBMC) were isolated and stained with the mAbs CD3-APC-Cy7, CD4-eFlour450, and CD8-PE-Cy7 for flow cytometry. (A) Representative flow cytometry contour plots of data from peripheral blood mononuclear cells show the ratio of CD4+ to CD8+ T-cells at 8 w post-infection (p.i.). (B) The numbers of CD4+ and CD8+ T-cells in peripheral blood samples obtained from infected animals were determined at the indicated time points and expressed as the percent of uninfected control animals. (C) The percentage of CD4+ and CD8+ T-cells in PBMC at the 8 w p.i. time point are shown. Data are presented as mean (± standard error) percent of control T-cells pooled from three independent experiments. * P <0.01 versus uninfected littermates.

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Journal of Neuroinflammation

ISSN: 1742-2094