Figure 5
T-cell reconstitution was lethal to herpes simplex virus-infected mice with murine acquired immunodeficiency syndrome. (A) Schematic representation of the experimental design. In brief, LP-BM5-infected murine acquired immunodeficiency syndrome (MAIDS) mice at 8 w post-infection were infected i.n. with 1 × 105 PFU of herpes simplex virus (HSV). At 7 d post-HSV infection, 2 × 106 or 5 × 106 CD3+ T-cells isolated from HSV-primed, major histocompatability complex (MHC)-matched C57BL/6 mice were intravenously transferred into the dual-infected MAIDS animals. (B) Following immune reconstitution the recipients were monitored for survival. Survival data are expressed as percent of mice in each group surviving at the indicated time point, followed over the time course of the experiment. * P <0.01, log rank test.