Reconstitution of T-cells from programmed death-1 knockout donors was immunopathogenic.
(A) In brief, C57BL/6 mice were infected with the LP-BM5 retrovirus mixture for 8 weeks to induce murine acquired immunodeficiency syndrome and brain super-infection with herpes simplex virus (HSV)-1 was established through i.n. inoculation. Immune reconstitution was induced following adoptive transfer of 2 × 106 CD3+ cells obtained from primed programmed death-1 knockout donor animals. (B) Following immune reconstituion the recipients were monitored for survival. Survival data are expressed as percent of mice in each group at the indicated time point. *P <0.01, log rank test.