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Table 1 LP-BM5 disease progression increases susceptibility of C57BL/6 mice to herpes simplex virus brain infection

From: T-cell reconstitution during murine acquired immunodeficiency syndrome (MAIDS) produces neuroinflammation and mortality in animals harboring opportunistic viral brain infection

LP-BM5 Trigeminal ganglia Brain stem
(weeks post-infection) (% positive) (% positive)
  Virus recovery RT PCR Virus recovery RT PCR
0 (n = 6) 100 100 0 0
2 (n = 3) 100 100 0 0
4 (n = 3) 100 100 0 0
6 (n = 6) 100 100 83 67
8 (n = 13) 100 100 76 53
  1. Susceptibility of mice with murine acquired immunodeficiency syndrome (MAIDS) to herpes simplex virus (HSV) brain infection; LP-BM5-infected C57BL/6 mice with MAIDS were super-infected with HSV at the indicated time points. Seven days post-HSV infection, the animals were sacrificed and tissues were harvested. The tissue was then divided into cortex, sub-cortex, brain stem, and trigeminal ganglia (TG). Data presented represents virus recovery from brain stem and TG. Data are expressed as percent positive in specific tissue. Total RNA extracted from trigeminal ganglia and brain stem of three to five mice/time point was reverse-transcribed and examined for the expression of HSV gD mRNA.