LP-BM5 | Trigeminal ganglia | Brain stem |
|---|
(weeks post-infection) | (% positive) | (% positive) |
|---|
| Â | Virus recovery | RT PCR | Virus recovery | RT PCR |
|---|
0 (n = 6) | 100 | 100 | 0 | 0 |
2 (n = 3) | 100 | 100 | 0 | 0 |
4 (n = 3) | 100 | 100 | 0 | 0 |
6 (n = 6) | 100 | 100 | 83 | 67 |
8 (n = 13) | 100 | 100 | 76 | 53 |
- Susceptibility of mice with murine acquired immunodeficiency syndrome (MAIDS) to herpes simplex virus (HSV) brain infection; LP-BM5-infected C57BL/6 mice with MAIDS were super-infected with HSV at the indicated time points. Seven days post-HSV infection, the animals were sacrificed and tissues were harvested. The tissue was then divided into cortex, sub-cortex, brain stem, and trigeminal ganglia (TG). Data presented represents virus recovery from brain stem and TG. Data are expressed as percent positive in specific tissue. Total RNA extracted from trigeminal ganglia and brain stem of three to five mice/time point was reverse-transcribed and examined for the expression of HSV gD mRNA.
