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Table 2 LP-BM5-infected programmed death-1 knockout animals retain resistance to herpes simplex virus brain infection

From: T-cell reconstitution during murine acquired immunodeficiency syndrome (MAIDS) produces neuroinflammation and mortality in animals harboring opportunistic viral brain infection

LP-BM5

Trigeminal ganglia

Brain stem

(8 weeks post-infection)

(% positive)

(% positive)

 

Virus recovery

RT PCR

Virus recovery

RT PCR

C57BL/6 (n = 8)

100

100

100

100

PD-1 KO (n = 7)

100

100

00

00

  1. LP-BM5-infected programmed death-1 (PD-1) knockout (KO) animals were resistant to herpes simplex virus (HSV) brain infection. PD-1 KO and C57BL/6 mice infected with LP-BM5 (8 w post-infection) were super-infected with HSV. At 7 d post-HSV infection animals were sacrificed and brain tissues were harvested. Data shown represent virus recovery from the brain stem and trigeminal ganglia. Data are expressed as percentage of positive tissues. Total RNA extracted from the trigeminal ganglia and brain stem of three to five mice/time point was reverse transcribed and examined for the expression of gD mRNA.
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