Table 10 Allele and genotype distributions of the SNPs in patients with or without maternal premature rupture of membrane (PROM)
From: The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy
| Â | Group | Allele frequency | P value | Genotype frequency | P value | Hardy-Weinberg equilibrium | |||
|---|---|---|---|---|---|---|---|---|---|
rs1800796 | Â | C | G | Â | C/C | C/G | G/G | Â | Â |
CP + PROM | 121 (0.695) | 53 (0.305) | 0.504 | 49 (0.563) | 23 (0.264) | 15 (0.172) | 0.006 a | 0.001 | |
CP − PROM | 856 (0.689) | 386 (0.311) | 0.292 | 298 (0.480) | 260 (0.419) | 63 (0.101) | 0.560 | 0.572 | |
| Â | Control | 992 (0.670) | 488 (0.330) | Â | 334 (0.451) | 324 (0.438) | 82 (0.111) | 0.011* b | 0.797 |
rs2069837 | Â | A | G | Â | A/A | A/G | G/G | Â | Â |
CP + PROM | 145 (0.824) | 31 (0.176) | 0.171 | 62 (0.705) | 21 (0.239) | 5 (0.057) | 0.231 | 0.095 | |
CP − PROM | 993 (0.805) | 241 (0.195) | 0.101 | 407 (0.660) | 179 (0.290) | 31 (0.050) | 0.243 | 0.056 | |
| Â | Control | 1134 (0.779) | 322 (0.221) | Â | 448 (0.615) | 238 (0.327) | 42 (0.058) | Â | 0.169 |
rs2066992 | Â | G | T | Â | G/G | G/T | T/T | Â | Â |
CP + PROM | 54 (0.307) | 122 (0.693) | 0.609 | 15 (0.170) | 24 (0.273) | 49 (0.557) | 0.005 c | 0.001 | |
CP − PROM | 387 (0.312) | 855 (0.688) | 0.425 | 62 (0.100) | 263 (0.424) | 296 (0.477) | 0.663 | 0.750 | |
| Â | Control | 483 (0.326) | 999 (0.674) | Â | 77 (0.104) | 329 (0.444) | 335 (0.452) | 0.012* d | 0.775 |
rs2069840 | Â | C | G | Â | C/C | C/G | G/G | Â | Â |
CP + PROM | 163 (0.926) | 13 (0.0734 | 0.377 | 75 (0.852) | 13 (0.148) | 0 (0.000) | 0.607 | 0.454 | |
CP − PROM | 1137 (0.911) | 111 (0.089) | 0.635 | 516 (0.827) | 105 (0.168) | 3 (0.005) | 0.889 | 0.339 | |
| Â | Control | 1346 (0.906) | 140 (0.094) | Â | 607 (0.817) | 132 (0.178) | 4 (0.005) | Â | 0.265 |
rs10242595 | Â | A | G | Â | A/A | A/G | G/G | Â | Â |
CP + PROM | 153 (0.879) | 21 (0.121) | 0.915 | 68 (0.782) | 17 (0.195) | 2 (0.023) | 0.990 | 0.459 | |
CP − PROM | 1102 (0.893) | 132 (0.107) | 0.371 | 492 (0.797) | 118 (0.191) | 7 (0.011) | 0.395 | 0.980 | |
| Â | Control | 1279 (0.882) | 171 (0.118) | Â | 569 (0.785) | 141 (0.194) | 15 (0.021) | Â | 0.079 |