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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Hypertonic saline alleviates cerebral edema by inhibiting microglia-derived TNF-α and IL-1β-induced Na-K-Cl Cotransporter up-regulation

Figure 5

HS attenuated hypoxia-induced TNF-α and IL-1β expression in microglia. Immunofluorescence images of cultured microglia showing the expression of Iba-1 (A, D, G, J, M, P, green), TNF-α (B, E, H, red) and IL-1β (K, N, Q, red). The co-localized expression of Iba-1 and TNF-α can be seen in panels D, F, I. The co-localized expression of Iba-1 and IL-1β can be seen in panels L, O, R. Note that TNF-α and IL-1β expression are markedly down-regulated in microglia after treatment with 100 mM HS as compared with the hypoxia group cells. Scale bars: (A-R), 20 μm. HS, hypertonic saline; IL-1β, interleukin- 1beta; TNF-α, tumor necrosis factor-alpha.

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