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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model

Figure 5

Astroglial CXCL10 deletion diminishes the acute accumulation of CD4 + lymphocytes in spinal cord perivascular spaces. (A) Representative cross-sectional images of lumbar spinal cord ventral fasciculi of an astroglial CXCL10 knockout and a control mouse 17 dpi, with perivascular spaces delineated by immunoreactive laminin (green) and CD4 (red). (B) Quantification of CD4+ T cells within the perivascular space surrounding the anterior spinal artery (P = 0.047). (C) Quantification of the area within laminin (n = 4–7 mice/group; P = 0.018). Vertical bars = SEMs.

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