Figure 2

Effect of adjudin on the activity of microglia after transient middle cerebral artery occlusion (tMCAO). Immunofluorescence staining of CD11b in the cerebral cortex and striatum (A) from mice that underwent sham surgery (sham, top panel), tMCAO followed by vehicle treatment (vehicle, middle panel) and tMCAO followed by adjudin treatment (adjudin, bottom panel) 3 d after reperfusion. Scale bar = 100 μm. Microglial activation in the ischemic cerebral cortex (B) and striatum (C) is quantified by the intensity of CD11b immunofluorescence. Data were mean ± SEM, N = 4 in each group. **P <0.01, ***P <0.005.