Figure 4

Adjudin inhibited ischemia/reperfusion induced blood-brain barrier destruction assayed by detection of IgG. Immunofluorescence staining for IgG (red) in the cerebral cortex and striatum from mice that underwent sham surgery (sham, top panel), transient middle cerebral artery occlusion (tMCAO) followed by vehicle treatment (vehicle, middle panel) and tMCAO followed by adjudin treatment (adjudin, bottom panel) 3 d after reperfusion, with DAPI staining for contrast. Merged images were shown at larger magnification, and scale bar =100 μm.