Cuprizone administration induces a less overt body weight decline in CXCR3-/- compared with wild type (WT) mice. From 8 weeks of age, WT and CXCR3-/- mice were fed with 0.2% cuprizone for five weeks (dotted grid lines) with a subsequent four days of recovery to normal chow (5.5 weeks). The body weights were monitored twice a week and plotted in comparison with values of control animals fed with powdered normal chow (gray symbols). During the initial three weeks of cuprizone feeding, CXCR3-/- animals showed a significantly less pronounced body weight decline than WT mice (n = 20 per group; **P <0.01, ***P <0.001). Moreover, body weight recovery after offset of cuprizone feeding was found to be significantly improved in CXCR3-deficient mice after 5.5 weeks (n = 7 per group; ***P <0.001). Data represent mean ± SEM.