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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Group I metabotropic glutamate receptor mediated dynamic immune dysfunction in children with fragile X syndrome

Figure 1

Peripheral blood mononuclear cells’ (PBMC) response to lipopolysaccharide (LPS) stimulation with a group I mGluR agonist. PBMC from children with fragile X syndrome (FXS) displayed an opposite or exaggerated immune response to LPS and (S)-3,5-dihydroxyphenylglycine (DHPG) relative to LPS alone when compared with typically developing (TD) controls for (A) IL-6 (P = 0.02), (B) IL-12(p40) (P < 0.01), and similar albeit non-significant trends for both (C) TNFα (P = 0.07) and (D) GM-CSF (P = 0.11). *P < 0.05, **P < 0.01.

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