Figure 2From: Group I metabotropic glutamate receptor mediated dynamic immune dysfunction in children with fragile X syndrome Peripheral blood mononuclear cells’ (PBMC) response to lipopolysaccharide (LPS) stimulation with a mGluR5 antagonist. PBMC from children with fragile X syndrome (FXS) displayed an opposite immune response to LPS and 3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride (MTEP) relative to LPS alone when compared with typically developing (TD) controls for (A) GM-CSF (P < 0.01). (B) IL-1β, (C) IL-6, and (D) IL-10 showed similar responses to MTEP in both subjects and controls. *P < 0.05, **P < 0.01.Back to article page