Skip to main content

Table 1 Cytokine levels in lipopolysaccharide (LPS)-stimulated and LPS plus DHPG-stimulated cell cultures

From: Group I metabotropic glutamate receptor mediated dynamic immune dysfunction in children with fragile X syndrome

 

TD

FXS

Cytokine

LPS

LPS + DHPG

P-value

LPS

LPS + DHPG

P-value

GM-CSF

50.4 (27.9 to 58.9)

39.6 (19.5 to 42.9)

0.04a

45.2 (17.7 to 70.7)

55.3 (20.1 to 107.2)

0.28

IL-1β

1,245.3 (957.4 to 1,855.5)

1,567.6 (1,160.2 to 2,235.0)

0.05a

1,146.0 (607.9 to 1,748.2)

2,326.9 (952.6 to 3,313.6)

< 0.01b

IL-6

3,203.9 (2,043.8 to 5,14.0)

2,856.1 (1,701.6 to 4,715.8)

0.33

2,900.2 (1,792.2 to 5,110.3)

4,366.9 (2,047.0 to 6,251.1)

0.21

IL-10

271.2 (106.3 to 765.6)

100.0 (85.0 to 515.8)

0.40

286.8 (184.0 to 573.0)

179.3 (76.3 to 342.1)

0.01b

IL-12(p40)

59.2 (36.9 to 72.5)

24.1 (16.3 to 51.2)

0.01a

25.0 (6.2 to 77.3)

46.1 (15.1 to 91.0)

0.37

TNFα

838.4 (626.3 to 1,034.4)

570.7 (485.1 to 914.5)

0.03a

724.2 (413.0 to 1,381.2)

1,010.4 (458.1 to 1,510.4)

0.49

  1. Values reported as median (interquartile range) in pg/mL. All P-values were calculated by Wilcoxon matched-pair signed-rank test. a P < 0.05; b P < 0.01. DHPG, (S)-3,5-dihydroxyphenylglycine; FXS, fragile X syndrome; TD, typically developing.