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Table 2 Cytokine levels in lipopolysaccharide (LPS)-stimulated and LPS plus MTEP-stimulated cell cultures

From: Group I metabotropic glutamate receptor mediated dynamic immune dysfunction in children with fragile X syndrome

 

TD

FXS

Cytokine

LPS

LPS + MTEP

P-value

LPS

LPS + MTEP

P-value

GM-CSF

50.4 (27.9 to 58.9)

39.8 (36.5 to 49.4)

0.35

45.2 (17.7 to 70.7)

25.5 (11.7 to 57.6)

< 0.01b

IL-1β

1,245.3 (957.4 to 1,855.5)

1,545.9 (972.5 to 2,312.1)

0.03a

1,146.0 (607.9 to 1,748.2)

1,558.4 (883.3 to 2,148.6)

< 0.01b

IL-6

3,203.9 (2,043.8 to 4,514.0)

4,195.3 (2,235.9 to 6,071.8)

0.12

2,900.2 (1,792.2 to 5,110.3)

3,969.3 (2,352.4 to 7,203.9)

0.01a

IL-10

271.2 (106.3 to 765.6)

415.6 (168.7 to 1,076.6)

0.03a

286.8 (184.0 to 573.0)

389.2 (210.4 to 608.2)

< 0.01b

IL-12(p40)

59.2 (36.9 to 72.5)

89.8 (17.3 to 101.8)

0.53

25.0 (6.2 to 77.3)

43.7 (22.5 to 96.3)

0.44

TNFα

838.4 (626.3 to 1,034.4)

922.5 (531.7 to 1,190.7)

0.75

724.2 (413.0 to 1,381.2)

925.1 (516.7 to 1,557.1)

0.93

  1. Values reported as median (interquartile range) in pg/mL. All P-values were calculated by Wilcoxon matched-pair signed-rank test. a P < 0.05; b P < 0.01. FXS, fragile X syndrome; MTEP, 3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride; TD, typically developing.