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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats

Figure 3

The effects of anti-CKLF1 antibody on production of TNF-α, IL-1β, MIP-2 and IL-8. Anti-CKLF1 antibody (0.1, 0.5 or 1 μg) was injected into the right cerebral ventricle immediately after reperfusion. Treatment with anti-CKLF1 antibody decreased the levels of TNF-α, IL-1β, MIP-2 and IL-8 in ischemic brain tissue in a dose-dependent manner. Each data point shows the mean ± SEM for five rats. ### P < 0.001, compared with sham-operated group; *P < 0.05, **P < 0.01, ***P < 0.001, compared with vehicle group. (A) TNF-α; (B) IL-1β; (C) IL-8; (D) MIP-2.

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Journal of Neuroinflammation

ISSN: 1742-2094