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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats

Figure 4

The effects of anti-CKLF1 antibody on expression of ICAM-1 and VCAM-1. Anti-CKLF1 antibody (0.1, 0.5 or 1 μg) was injected into the right cerebral ventricle immediately after reperfusion. ICAM-1 and VCAM-1 mRNA and protein expression were measured. Treatment with anti-CKLF1 antibody decreased the expression of ICAM-1 and VCAM-1 in ischemic brain tissue. (A) mRNA of ICAM-1, (B) mRNA of VCAM-1, (C) protein of ICAM-1, (D) protein of VCAM-1. Each data point shows the mean ± SEM for five rats. # P < 0.05, ## P < 0.01, compared with sham-operated group; *P < 0.05, **P < 0.01 compared with vehicle group.

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