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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats

Figure 5

The effect of anti-CKLF1 antibody on neutrophils infiltration. Anti-CKLF1 antibody (0.1, 0.5 or 1 μg) was injected into the right cerebral ventricle immediately after reperfusion. Brain sections were stained with anti-MPO antibody. The MPO-positive neutrophils (indicated by arrowhead) were localized in the ischemic cortex. Treatment with anti-CKLF1 antibody decreased the numbers of MPO-positive neutrophils. The ischemic core region in cerebral cortex is indicated by pane. Cells indicated by black arrows are MPO-positive cells (brown). Each data point shows the mean ± SEM for four rats. ### P < 0.001, compared with sham-operated group; **P < 0.01, ***P < 0.001, compared with vehicle group. Typical photograph from (A) sham-operated group, (B) vehicle group, (C) vehicle + IgG (1 μg), (D) anti-CKLF1 antibody (0.1 μg), (E) anti-CKLF1 antibody (0.5 μg), and (F) anti-CKLF1 antibody (1 μg) respectively. Bar = 100 μm.

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Journal of Neuroinflammation

ISSN: 1742-2094