Figure 3
From: Glimepiride reduces CD14 expression and cytokine secretion from macrophages
Glimepiride reduces cytokine secretion from RAW 264 cells incubated with Aβ. (A) The concentrations of TNF produced by RAW 264 cells incubated with Aβ1–42 (●), Aβ42–1 (■) or Aβ1–42 and 1 μg/ml polymyxin B (□). Values are means ± SD from triplicate experiments performed 4 times, n = 12. (B) The concentrations of TNF produced by RAW 264 cells pre-treated with control medium (●) 5 μM glimepiride (○) or 5 μM glipizide (□) and incubated with Aβ1–42. Values are means ± SD from triplicate experiments performed 4 times, n = 12. (C) The concentrations of IL-1β produced by RAW 264 cells pre-treated with control medium (●) 5 μM glimepiride (○) or 5 μM glipizide (□) and incubated with Aβ1–42. Values are means ± SD from triplicate experiments performed 4 times, n = 12. (D) The concentrations of IL-6 produced by RAW 264 cells pre-treated with control medium (●), 5 μM glimepiride (○) or 5 μM glipizide (□) and incubated with Aβ1–42. Values are means ± SD from triplicate experiments performed 4 times, n = 12.