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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Glimepiride reduces CD14 expression and cytokine secretion from macrophages

Figure 3

Glimepiride reduces cytokine secretion from RAW 264 cells incubated with Aβ. (A) The concentrations of TNF produced by RAW 264 cells incubated with Aβ1–42 (), Aβ42–1 (■) or Aβ1–42 and 1 μg/ml polymyxin B (□). Values are means ± SD from triplicate experiments performed 4 times, n = 12. (B) The concentrations of TNF produced by RAW 264 cells pre-treated with control medium () 5 μM glimepiride () or 5 μM glipizide (□) and incubated with Aβ1–42. Values are means ± SD from triplicate experiments performed 4 times, n = 12. (C) The concentrations of IL-1β produced by RAW 264 cells pre-treated with control medium () 5 μM glimepiride () or 5 μM glipizide (□) and incubated with Aβ1–42. Values are means ± SD from triplicate experiments performed 4 times, n = 12. (D) The concentrations of IL-6 produced by RAW 264 cells pre-treated with control medium (), 5 μM glimepiride () or 5 μM glipizide (□) and incubated with Aβ1–42. Values are means ± SD from triplicate experiments performed 4 times, n = 12.

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