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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Glimepiride reduces CD14 expression and cytokine secretion from macrophages

Figure 6

RAW264 and microglial cells recover from glimepiride-induced suppression of cytokine production. (A) The amounts of CD14 in RAW 264 cells treated with control medium (□) or 5 μM glimepiride for time periods as shown (■). Values are means ± SD from triplicate experiments performed twice, n = 6. (B) The concentrations of TNF produced by RAW 264 cells pre-treated with control medium (□) or 5 μM glimepiride for time periods as shown (■) and incubated with 50 μM PrP82-146 for 24 hours. Values are means ± SD from triplicate experiments performed twice, n = 6. (C) The amounts of CD14 in microglial cells treated with control medium (□) or 5 μM glimepiride for time periods as shown (■). Values are means ± SD from triplicate experiments performed twice, n = 6. (D) The concentrations of TNF produced by microglial cells pre-treated with control medium (□) or 5 μM glimepiride for time periods as shown (■) and incubated with 50 μM PrP82-146 for 24 hours. Values are means ± SD from triplicate experiments performed twice, n = 6.

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