Platelet-activating factors are associated with cognitive deficits in depressed coronary artery disease patients: a hypothesis-generating study

Table 3 Pearson correlations between PAFs and global cognitive performance (composite z score) in patients with CAD

PAF species ( m/zpeak and identities)	All patients (N = 24)		Major depressed subgroup (N = 15)
PAF species ( m/zpeak and identities)	Pearson coefficient ( r)	P	Pearson coefficient ( r)	P
(468.3a) PC(O-12:0/2:0)	-0.09	0.67	0.33	0.23
(482.4a) PC(O-13:0/2:0)	0.17	0.44	0.19	0.49
(496.3a) PC(O-14:0/2:0)	-0.22	0.31	-0.39	0.16
(494.3a) PC(O-14:1/2:0)	-0.22	0.30	0.26	0.36
(510.4d) PC(O-15:0/2:0)	0.20	0.36	-0.12	0.66
(482.4c) PC(O-16:0/0:0)	-0.27	0.21	-0.53	0.04*
(524.4a) PC(O-16:0/2:0)	-0.35	0.09*	-0.52	0.04*
(522.4a) PC(O-16:1/2:0)	0.06	0.78	-0.03	0.92
(520.3a) PC(O-16:2/2:0)	-0.08	0.72	-0.03	0.92
(532.3a) PC(O-17:3/2:0)	0.00	0.99	0.12	0.68
(510.4d) PC(O-18:0/0:0)	-0.08	0.73	-0.04	0.89
(552.4e) PC(O-18:0/2:0)	-0.45	0.03*	-0.59	0.02*
(508.6b) PC(O-18:1/0:0)	0.22	0.31	0.45	0.09*
(550.4a) PC(O-18:1/2:0)	-0.37	0.08*	-0.47	0.08*
(548.4b) PC(O-18:2/2:0)	-0.10	0.64	0.14	0.61
(546.3a) PC(O-18:3/2:0)	-0.15	0.50	0.19	0.50
(544.4a) PC(O-18:4/2:0)	0.14	0.51	0.16	0.55
(542.3b) PC(O-18:5/2:0)	-0.08	0.69	0.28	0.31
(540.4a) PC(O-18:6/2:0)	-0.40	0.05*	-0.49	0.06*
(556.4d) PC(O-19:5/2:0)	0.12	0.59	0.55	0.03^†
(572.3b) PC(O-20:4/2:0)	0.09	0.68	0.32	0.25
(570.3e) PC(O-20:5/2:0)	-0.29	0.16	0.03	0.92
(568.4a) PC(O-20:6/2:0)	-0.16	0.46	0.14	0.61

Nomenclature adheres to the recent reorganization of ontologies for lipid classes and the curated list of lipid species identified by the Canadian Institutes of Health Research Training Program in Neurodegenerative Lipidomics (CTPNL) teams [28, 30]. PC(O-20:4/2:0), for example, defines a lipid species with a phosphocholine polar head group (PC), an ether linkage at the sn-1 position (O-) with a chain of 20 carbons and 2 carbons linked by an ester linkage at the sn-2 position, of which the sn-1 chain has four degrees of unsaturation (indicated as: 4) whereas the sn-2 chain is characterized by fully saturated acetyl group (referred to by: 0). The number preceding species name in brackets refers to m/z of the [M + H]⁺ ion. Letters distinguish species isobaric with other lipid second messengers in the curated CTPNL phospholipid list. *Significant negative associations (P ≤ 0.05); ^†significant positive associations (P ≤ 0.05); CAD, coronary artery disease; PAF, platelet-activating factor.

ISSN: 1742-2094