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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline

Figure 3

CCR2 and CCR4 signaling play a role in the progression of hepatic encephalopathy. (A) Representative immunoblots against CCR2 and CCR4 in vehicle- and AOM-treated cortex lysates. (B) Time to coma, in hours, of mice treated with AOM, AOM + INCB, or AOM + C021, n = 4. (C) Neurological score of mice treated with AOM, AOM + INCB, or AOM + C021, n = 4. Neurological score calculations are outlined in the methods section. (D) Serum ALT levels in mice treated with vehicle, AOM, AOM + INCB, or AOM + C021. (E) Bilirubin concentrations in serum for mice administered vehicle, AOM, AOM + INCB, or AOM + C021. (F) Hematoxylin and eosin stains in liver sections from mice treated with vehicle, AOM, AOM + INCB, or AOM + C021. For time to coma analyses, * P <0.05 compared to AOM-treated mice. For ALT and bilirubin assays, * P <0.05 compared to vehicle-treated mice, # P <0.05 compared to AOM-treated mice.

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