IFNγ causes an increase in CD11b staining. (A-D) Dentate gyrus of wild-type (WT) mice receiving GFP-AAV or IFNγ-AAV. (E-H) Dentate gyrus of APP/PS1 mice receiving GFP-AAV or IFNγ-AAV. (I) Quantification of CD11b in the frontal cortex, CA1, CA3, and DG. **P < 0.01, IFNγ-AAV compared to GFP-AAV at that time point and genotype. #P < 0.05, ##P < 0.01, 4-month IFNγ-AAV compared to 6-month IFNγ-AAV of that genotype. Scale bar in A is for A-H and is equal to 50 μm. AAV, adeno-associated virus; DG, dentate gyrus, GFP, green fluorescent protein; IFN, interferon.