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Table 2 Fold change values for real time PCR

From: Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice

 

GFP-AAV

IFNγ-AAV

WT

APP/PS1

WT

APP/PS1

Gene

4 mo

6 mo

4 mo

6 mo

4 mo

6 mo

4 mo

6 mo

IL-6

1.5 ± 0.51

1.4 ± 0.45

2.46 ± 1.36

1.16 ± 0.21

5.27 ± 2.8

92.42 ± 81.72

12.23 ± 7.43

15.03 ± 5.81

IL-1β

1.7 ± 0.72

1.2 ± 0.27

1.42 ± 0.57

1.15 ± 0.23

26.55 ± 8.8

3673.4 ± 3599.1

77.75 ± 31.53

96.07 ± 25.74

IL-12a

1.62 ± 0.68

1.25 ± 0.38

1.75 ± 0.79

1.4 ± 0.44

3.62 ± 1.9

29.53 ± 0.43

5.37 ± 3.92

89.85 ± 60.30

IL-12b

1.37 ± 0.94

1.29 ± 0.39

1.14 ± 0.43

1.68 ± 0.76

108.96 ± 36.47

109.55 ± 79.82

128.58 ± 103.11

239.43 ± 77.25

ARG1

1.95 ± 0.79

1.19 ± 0.34

1.41 ± 0.45

1.88 ± 0.75

0.55 ± 0.09

1.68 ± 0.30

0.49 ± 0.12

2.02 ± 0.36

YM1

1.87 ± 1.06

1.08 ± 0.19

1.31 ± 0.51

2.35 ± 1.17

2.91 ± 1.12

184.47 ± 174.22

6.48 ± 4.07

68.66 ± 23.88

CD86

1.21 ± 0.3

1.56 ± 0.66

1.09 ± 0.22

1.3 ± 0.93

21.2 ± 4.97

24.9 ± 4.51

66.85 ± 43.23

19.93 ± 7.52

FcγR1

1.2 ± 0.28

1.10 ± 0.24

1.12 ± 0.26

1.36 ± 0.55

13.45 ± 3.05

59 ± 34.83

9.11 ± 2.61

18.44 ± 2.65

FcγR3

1.49 ± 0.46

1.05 ± 0.15

1.14 ± 0.31

1.27 ± 0.44

4.9 ± 0.83

36.28 ± 10.41

4.89 ± 1.61

13.64 ± 1.17

TGFβ1

1.45 ± 0.61

1.29 ± 0.40

1.07 ± 0.19

1.23 ± 0.26

1.58 ± 0.33

3.53 ± 0.83

1.95 ± 0.28

1.95 ± 0.74

SPHK1

2.01 ± 1.28

1.07 ± 0.18

1.46 ± 0.60

1.58 ± 0.77

0.06 ± 0.02

8.23 ± 2.69

0.19 ± 0.03

2.21 ± 0.28

  1. Bold font indicates P < 0.05 compared to GFP-AAV of that time point and genotype. AAV, adeno-associated virus; ARG1, arginase 1; FcγR, Fc gamma receptor; GFP, green fluorescent protein; IFN, interferon; IL, interleukin; mo, months; SPHK1, sphingosine kinase 1; TGF, transforming growth factor; WT, wild-type.