GFP-AAV | IFNγ-AAV | |||||||
---|---|---|---|---|---|---|---|---|
WT | APP/PS1 | WT | APP/PS1 | |||||
Gene | 4 mo | 6 mo | 4 mo | 6 mo | 4 mo | 6 mo | 4 mo | 6 mo |
IL-6 | 1.5 ± 0.51 | 1.4 ± 0.45 | 2.46 ± 1.36 | 1.16 ± 0.21 | 5.27 ± 2.8 | 92.42 ± 81.72 | 12.23 ± 7.43 | 15.03 ± 5.81 |
IL-1β | 1.7 ± 0.72 | 1.2 ± 0.27 | 1.42 ± 0.57 | 1.15 ± 0.23 | 26.55 ± 8.8 | 3673.4 ± 3599.1 | 77.75 ± 31.53 | 96.07 ± 25.74 |
IL-12a | 1.62 ± 0.68 | 1.25 ± 0.38 | 1.75 ± 0.79 | 1.4 ± 0.44 | 3.62 ± 1.9 | 29.53 ± 0.43 | 5.37 ± 3.92 | 89.85 ± 60.30 |
IL-12b | 1.37 ± 0.94 | 1.29 ± 0.39 | 1.14 ± 0.43 | 1.68 ± 0.76 | 108.96 ± 36.47 | 109.55 ± 79.82 | 128.58 ± 103.11 | 239.43 ± 77.25 |
ARG1 | 1.95 ± 0.79 | 1.19 ± 0.34 | 1.41 ± 0.45 | 1.88 ± 0.75 | 0.55 ± 0.09 | 1.68 ± 0.30 | 0.49 ± 0.12 | 2.02 ± 0.36 |
YM1 | 1.87 ± 1.06 | 1.08 ± 0.19 | 1.31 ± 0.51 | 2.35 ± 1.17 | 2.91 ± 1.12 | 184.47 ± 174.22 | 6.48 ± 4.07 | 68.66 ± 23.88 |
CD86 | 1.21 ± 0.3 | 1.56 ± 0.66 | 1.09 ± 0.22 | 1.3 ± 0.93 | 21.2 ± 4.97 | 24.9 ± 4.51 | 66.85 ± 43.23 | 19.93 ± 7.52 |
FcγR1 | 1.2 ± 0.28 | 1.10 ± 0.24 | 1.12 ± 0.26 | 1.36 ± 0.55 | 13.45 ± 3.05 | 59 ± 34.83 | 9.11 ± 2.61 | 18.44 ± 2.65 |
FcγR3 | 1.49 ± 0.46 | 1.05 ± 0.15 | 1.14 ± 0.31 | 1.27 ± 0.44 | 4.9 ± 0.83 | 36.28 ± 10.41 | 4.89 ± 1.61 | 13.64 ± 1.17 |
TGFβ1 | 1.45 ± 0.61 | 1.29 ± 0.40 | 1.07 ± 0.19 | 1.23 ± 0.26 | 1.58 ± 0.33 | 3.53 ± 0.83 | 1.95 ± 0.28 | 1.95 ± 0.74 |
SPHK1 | 2.01 ± 1.28 | 1.07 ± 0.18 | 1.46 ± 0.60 | 1.58 ± 0.77 | 0.06 ± 0.02 | 8.23 ± 2.69 | 0.19 ± 0.03 | 2.21 ± 0.28 |