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Table 2 Fold change values for real time PCR

From: Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice

  GFP-AAV IFNγ-AAV
WT APP/PS1 WT APP/PS1
Gene 4 mo 6 mo 4 mo 6 mo 4 mo 6 mo 4 mo 6 mo
IL-6 1.5 ± 0.51 1.4 ± 0.45 2.46 ± 1.36 1.16 ± 0.21 5.27 ± 2.8 92.42 ± 81.72 12.23 ± 7.43 15.03 ± 5.81
IL-1β 1.7 ± 0.72 1.2 ± 0.27 1.42 ± 0.57 1.15 ± 0.23 26.55 ± 8.8 3673.4 ± 3599.1 77.75 ± 31.53 96.07 ± 25.74
IL-12a 1.62 ± 0.68 1.25 ± 0.38 1.75 ± 0.79 1.4 ± 0.44 3.62 ± 1.9 29.53 ± 0.43 5.37 ± 3.92 89.85 ± 60.30
IL-12b 1.37 ± 0.94 1.29 ± 0.39 1.14 ± 0.43 1.68 ± 0.76 108.96 ± 36.47 109.55 ± 79.82 128.58 ± 103.11 239.43 ± 77.25
ARG1 1.95 ± 0.79 1.19 ± 0.34 1.41 ± 0.45 1.88 ± 0.75 0.55 ± 0.09 1.68 ± 0.30 0.49 ± 0.12 2.02 ± 0.36
YM1 1.87 ± 1.06 1.08 ± 0.19 1.31 ± 0.51 2.35 ± 1.17 2.91 ± 1.12 184.47 ± 174.22 6.48 ± 4.07 68.66 ± 23.88
CD86 1.21 ± 0.3 1.56 ± 0.66 1.09 ± 0.22 1.3 ± 0.93 21.2 ± 4.97 24.9 ± 4.51 66.85 ± 43.23 19.93 ± 7.52
FcγR1 1.2 ± 0.28 1.10 ± 0.24 1.12 ± 0.26 1.36 ± 0.55 13.45 ± 3.05 59 ± 34.83 9.11 ± 2.61 18.44 ± 2.65
FcγR3 1.49 ± 0.46 1.05 ± 0.15 1.14 ± 0.31 1.27 ± 0.44 4.9 ± 0.83 36.28 ± 10.41 4.89 ± 1.61 13.64 ± 1.17
TGFβ1 1.45 ± 0.61 1.29 ± 0.40 1.07 ± 0.19 1.23 ± 0.26 1.58 ± 0.33 3.53 ± 0.83 1.95 ± 0.28 1.95 ± 0.74
SPHK1 2.01 ± 1.28 1.07 ± 0.18 1.46 ± 0.60 1.58 ± 0.77 0.06 ± 0.02 8.23 ± 2.69 0.19 ± 0.03 2.21 ± 0.28
  1. Bold font indicates P < 0.05 compared to GFP-AAV of that time point and genotype. AAV, adeno-associated virus; ARG1, arginase 1; FcγR, Fc gamma receptor; GFP, green fluorescent protein; IFN, interferon; IL, interleukin; mo, months; SPHK1, sphingosine kinase 1; TGF, transforming growth factor; WT, wild-type.