Experiment | Wild type | IRF3−/−
|
---|
1 | 7/7 (100%) | 5/6 (83%) |
2 | 4/6 (67%) | 7/7 (100%) |
3 | 5/5 (100%) | 2/8 (25%) |
4 | 6/6 (100%) | 1/6 (17%) |
5 | 4/5 (80%) | 2/5 (40%) |
Total | 26/29 (90%) | 17/32 (53%) |
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aWild-type and interferon regulatory factor 3–knockout (irf3
−/−) mice were immunised with myelin oligodendrocyte glycoprotein (MOG35–55) in Complete Freund’s adjuvant, and Bordetella pertussis toxin was administered on day 0 and day 2. Mice were scored daily for clinical signs of experimental autoimmune encephalomyelitis. Data represent disease incidence in each group in five independent experiments.