Experiment
|
Wild type
|
IRF3−/−
|
---|
1
|
7/7 (100%)
|
5/6 (83%)
|
2
|
4/6 (67%)
|
7/7 (100%)
|
3
|
5/5 (100%)
|
2/8 (25%)
|
4
|
6/6 (100%)
|
1/6 (17%)
|
5
|
4/5 (80%)
|
2/5 (40%)
|
Total
|
26/29 (90%)
|
17/32 (53%)
|
-
aWild-type and interferon regulatory factor 3–knockout (irf3
−/−) mice were immunised with myelin oligodendrocyte glycoprotein (MOG35–55) in Complete Freund’s adjuvant, and Bordetella pertussis toxin was administered on day 0 and day 2. Mice were scored daily for clinical signs of experimental autoimmune encephalomyelitis. Data represent disease incidence in each group in five independent experiments.