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Table 1 Incidence of actively induced experimental autoimmune encephalomyelitis in wild-type and irf3 −/− mice a

From: Interferon regulatory factor (IRF) 3 is critical for the development of experimental autoimmune encephalomyelitis

Experiment Wild type IRF3−/−
1 7/7 (100%) 5/6 (83%)
2 4/6 (67%) 7/7 (100%)
3 5/5 (100%) 2/8 (25%)
4 6/6 (100%) 1/6 (17%)
5 4/5 (80%) 2/5 (40%)
Total 26/29 (90%) 17/32 (53%)
  1. aWild-type and interferon regulatory factor 3–knockout (irf3 −/−) mice were immunised with myelin oligodendrocyte glycoprotein (MOG35–55) in Complete Freund’s adjuvant, and Bordetella pertussis toxin was administered on day 0 and day 2. Mice were scored daily for clinical signs of experimental autoimmune encephalomyelitis. Data represent disease incidence in each group in five independent experiments.