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Table 2 Incidence of adoptively transferred experimental autoimmune encephalomyelitis with CD4 + cells from irf3 −/− and wild-type donors a

From: Interferon regulatory factor (IRF) 3 is critical for the development of experimental autoimmune encephalomyelitis

Experiment WT to WT irf3−/−to WT WT to irf3 −/−
1 6/6 (100%) 0/4 (0%) 0/6 (0%)
2 7/7 (100%) 0/4 (0%)
3 4/5 (80%) 0/5 (0%)
4 3/3 (100%) 0/5 (0%)
Total 20/21 (95%) 0/13 (0%) 0/11 (0%)
  1. aWild-type (WT) and interferon regulatory factor 3–knockout (irf3 −/−) mice were immunised with myelin oligodendrocyte glycoprotein (MOG35–55) in complete Freund’s adjuvant medium. After 10 days, cells from spleens and lymph nodes were reactivated with MOG35–55 in the presence of interleukin-23 for 3 days. Cells were transferred intravenously into naive WT or irf3 −/− recipient mice that received Bordetella pertussis toxin on day 0 and day 2 after cell transfer. Mice were scored daily for clinical signs of disease. Data represent disease incidence in each group in two to four independent experiments, and headings describe donor-to-recipient transfers.