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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Complex pattern of interaction between in uterohypoxia-ischemia and intra-amniotic inflammation disrupts brain development and motor function

Figure 5

Injury impacts erythropoietin ligand and receptor mRNA levels. (A) At postnatal day 2 (P2), erythropoietin receptor (EPOR) mRNA levels are significantly higher in transient systemic hypoxia-ischemia (TSHI) pups compared to sham levels, without a concomitant increase in erythropoietin (EPO) ligand mRNA levels (n = 5-14, ***P < 0.001). (B) By P15 no significant differences in EPO or EPOR mRNA exists between injury groups (n = 3-7). (C) The patterns of the ratio of EPO ligand to EPO receptor shift from P2 to P15, with sustained ligand to receptor mismatch in TSHI pups, in contrast to the shift observed in pups exposed to lipopolysaccharide (LPS) or TSHI + LPS. The persistent ligand deficiency correlates with the sustained loss of myelin basic protein and the reduced phosphoneurofilament/neurofilament ratio observed at P28 in TSHI white matter, but not LPS or TSHI + LPS white matter.

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Journal of Neuroinflammation

ISSN: 1742-2094