|
Gene expression (fold increase 24 hours post-intraperitoneal LPS)
|
|---|
| |
IL-1β
|
IL-6
|
TNFα
|
CCL2
|
|---|
|
Hypothalamus
|
6.40 ± 0.79**
|
2.18 ± 0.42*
|
22.51 ± 1.09***
|
1.33 ± 0.72*
|
|
Hippocampus
|
23.02 ± 0.30***
|
17.88 ± 1.22*
|
77.71 ± 0.74***
|
24.01 ± 1.74*
|
|
Choroid plexus
|
6.93 ± 0.78**
|
2.29 ± 0.98*
|
1477.8 ± 1.25***
|
2.29 ± 0.98 (ns)
|
- Adult 8-week-old C57BL/6 J female mice were injected intraperitoneally with saline (0.9% NaCl) or 2 mg/kg lipopolysaccharide (LPS). Brains were dissected 24 hours later and pro-inflammatory genes for IL-1β, IL-6, TNFα and CCL2 were determined by quantitative PCR from the hypothalamus, hippocampus and choroid plexus. *P < 0.05, **P < 0.01, ***P < 0.005 versus saline controls; ns, not significant, n = 4.
