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Table 1 Peripheral lipopolysaccharide administration induced M1-type pro-inflammatory cytokine/chemokine mRNA profiles in mouse brain

From: Molecular and cellular neuroinflammatory status of mouse brain after systemic lipopolysaccharide challenge: importance of CCR2/CCL2 signaling

Gene expression (fold increase 24 hours post-intraperitoneal LPS)
  IL-1β IL-6 TNFα CCL2
Hypothalamus 6.40 ± 0.79** 2.18 ± 0.42* 22.51 ± 1.09*** 1.33 ± 0.72*
Hippocampus 23.02 ± 0.30*** 17.88 ± 1.22* 77.71 ± 0.74*** 24.01 ± 1.74*
Choroid plexus 6.93 ± 0.78** 2.29 ± 0.98* 1477.8 ± 1.25*** 2.29 ± 0.98 (ns)
  1. Adult 8-week-old C57BL/6 J female mice were injected intraperitoneally with saline (0.9% NaCl) or 2 mg/kg lipopolysaccharide (LPS). Brains were dissected 24 hours later and pro-inflammatory genes for IL-1β, IL-6, TNFα and CCL2 were determined by quantitative PCR from the hypothalamus, hippocampus and choroid plexus. *P < 0.05, **P < 0.01, ***P < 0.005 versus saline controls; ns, not significant, n = 4.