CD68 expression in the OS after 15 days of unilateral laser-induced OHT. Double immunostaining: Iba-1/CD68. Retinal whole-mount. In naïve eyes (A, B) CD68 immunostaining was observed in type 1 OS Iba-1+ cells (blank arrow). In the OS in contralateral eyes (C, D) ameboid Iba-1+ cells (blank arrowhead) had a greater CD68 immunostaining than type 1 OS (arrowhead) and type 2 OS (inset) Iba-1+ cells. In OHT eyes (E-H) CD68 immunostaining in the OS was observed in ameboid Iba-1+ cells (blank arrowhead in E, F), rounded Iba-1+ cells (arrow in E, F) and in the soma and processes of type 2 OS Iba-1+ cells (G, H). (OHT: ocular hypertension; OS: photoreceptor outer segment).