Figure 6

Survival upon CpG ODN pre-treatment correlated with high levels of IL-12/IL-23p40 and MIP-1α. Cyto-/chemokine concentrations in (A, B) cerebellar and (C, D) spleen homogenates and (E) serum from CpG- (n = 20) and buffer-treated (n = 10) mice were measured 14 days after intracerebral E. coli K1 infection. Each symbol represents an individual neutropenic mouse. Horizontal bars indicate median values. Statistical analysis was performed by Mann-Whitney U test.