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Table 1 Subpopulations of T cells in the CNS of CpG- and buffer-treated neutropenic mice 42 h after infection

From: Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection

 

Absolute no. of cellsa

Percent among all CD45+cellsa

 

CpG

Buffer

CpG

Buffer

CD45+ cells

237427 (122770/257348)

228016 (169274/314119)

  

T cells (CD45+CD3+)

4274 (3560/4607)

4844 (3065/8602)

2 (1.8/2.9)b

3.2 (2.8/3.6)

Regulatory T cells CD45+CD4+CD3+CD25+FoxP3+

172 (122/307)

375 (167/489)

0.08 (0.06/0.13)b

0.2 (0.12/0.55)

NK cells CD45+NK1.1+CD3-

3631 (3138/7180)

2588 (1882/6996)

2.6 (1.6/3)

2.2 (1.5/3.6)

Inflammatory monocytes CD45+CD11b+Ly6ChighCCR2+

66905 (46994/101306)

40683 (23199/55803)

39.4 (27.6/46.9)b

25.9 (23.3/28.9)

Monocytes CD45+CD11b+Ly6ChighCCR2-

13798 (6089/22579)

13150 (7054/24206)

7 (4.9/11)

8.54 (5/11.7)

Monocytes CD45+CD11b+Ly6CintCCR2-

40918 (15076/69499)

39167 (19894/65079)

22 (15.9/27.51)

26.4 (17.35/34)

Microglia CD45intCD11bintLy6C-

6392 (4150/27330)

5316 (2869/18381)

3.56 (2.6/10.62)

4.69 (2.48/7.71)

  1. aData are medians (25th/75th percentiles) determined by forward and side-scatter properties from the right hemisphere of animals (n = 6-7/group) of at least three separate experiments.
  2. bSignificantly different (P <0.05) vs. buffer-treated group (Mann-Whitney U test).