Table 1 IPA annotation of the top canonical pathways altered by EGCG in LPS-stimulated BV-2 cells

NRF2-mediated oxidative stress response

1.9E-11

11/192 (0.057)

ACTB, AKR1A1, CLPP, ERP29, GSTO1, HMOX1, PRDX1, SOD1, SOD2, STIP1, USP14

Protein ubiquitination pathway

2.6E-05

7/268 (0.026)

HSPA5, HSPA8, HSPD1, PSMA1, PSMB2, PSMD7, USP14

Valine degradation I

0.00022

3/35 (0.086)

DBT, DLD, HIBCH

Superoxide radicals degradation

0.00031

2/8 (0.25)

SOD1, SOD2

Branched-chain α-Keto acid dehydrogenase complex

0.0004

2/9 (0.222)

DBT, DLD