Figure 3

Ex vivo levels of CD80 ⁺ B cells correlate with disease severity, whereas total B cell (CD19 ⁺ ) levels decrease overtime in HAM/TSP patients. (A) Positive correlation between the percentage of CD80 in B cells (CD19⁺) and Kurtzke’s EDSS. (***p = 0.0006, Spearman’s r = 0.73, n = 18). (B) Ex vivo CD19⁺ B cell level is negatively correlated to disease duration in HAM/TSP patients (n = 21). (***p = 0.0003, Spearman’s r = 0.72, n = 21).