Figure 5

Survival rates of the CD8 ^−/− , RAG ^−/−, and iNOS ^−/− mice after the HSV-1 infection. Mice were inoculated with 10⁶ p.f.u. of HSV-1 (n = 10 for each group), and the mouse mortality was measured daily. C57BL/6 (circle), CD8^−/− (square), iNOS^−/− (diamonds), and RAG^−/− (triangle). The statistical analyses were performed using the log-rank test. ***P <0.001, when comparing survival from C57BL/6 to each group of knockout mice. This experiment is representative of two analyses.